Search results for "C4b-binding protein"

showing 3 items of 3 documents

Immunonephelometric determination of the C4b-binding protein.

1993

A fully mechanised immunonephelometric method for the rapid and specific determination of C4b-binding protein (C4b-BP) in citrated plasma is described. The method utilizes commercially available rabbit antiserum against human C4b-BP and a nephelometer analyser. A single determination can be performed within 6 min, requiring 80 microliters sample volume. The measuring range is about 10 to 200% of normal C4b-BP. Precision is characterized by intraassay coefficients of variation between 1.5% and 2.8%, and interassay coefficients of variation between 4.0% and 4.6% for the same C4b-BP concentrations. The nephelometry of C4b-BP was correlated with electroimmunodiffusion (Laurell technique; r = 0.…

AdultMalePercentileImmunodiffusionAnalytical chemistryAdministration Oralchemical and pharmacologic phenomenaFibrinogenRabbit antiserumNephelometry and TurbidimetryBlood plasmamedicineComplement C4bHumansAgedGlycoproteinsInflammationComplement Inactivator ProteinsChromatographyChemistryC4b-binding proteinHeparinHealthy subjectsAnticoagulantsHematologyMiddle AgedEvaluation Studies as TopicFemaleCarrier ProteinsQuantitative analysis (chemistry)Nephelometrymedicine.drugThrombosis research
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C4BPB/C4BPA is a new susceptibility locus for venous thrombosis with unknown protein S-independent mechanism: results from genome-wide association an…

2010

3 Figures. 2 Tables. The online version of this article contains a data supplement.

MaleImmunologySingle-nucleotide polymorphismGenome-wide association studyLocus (genetics)ThrombophiliaBiochemistryPolymorphism Single NucleotideProtein SProtein SRisk FactorsHistocompatibility AntigensMedicineHumansGenetic Predisposition to DiseaseAlleleGeneticsVenous ThrombosisClinical Trials as Topicbiologybusiness.industryC4b-binding proteinComplement C4b-Binding ProteinCase-control studyCell BiologyHematologymedicine.diseasePS-independentprotein (C4BP)Gene Expression RegulationGenetic LociCase-Control Studiesprotein S (PS)biology.proteinFemalebusinessGenome-Wide Association Study
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The Complement System: Activation and Control

1985

One of the hallmarks of immunology has been analysis and characterization of the C system in biological fluids. It is composed of 11 proteins of the “classical” pathway:1 C1q, C1r, C1s, C4, C2, C3, C5, C6, C7, C8, and C9. There are three proteins of the “alternative” pathway (IUIS-WHO Nomenclature Committee 1981) B, D, and P. Finally, there are four control proteins: C1 inhibitor (Cl¯ INH) and C4b binding protein (C4b-bp) for the classical pathway, I (C3b inactivator or C3b INA) and H (β1 or C3b INA accelerator) for the alternative pathway, and anaphylatoxin inactivator. Due to the dramatic advances in protein chemistry, these 19 distinct serum proteins have been highly purified and charact…

biologyC4b-binding proteinChemistrychemical and pharmacologic phenomenaBlood proteinsComplement systemC1-inhibitorClassical complement pathwayBiochemistryImmunologybiology.proteinAlternative complement pathwayLysine carboxypeptidaseComplement membrane attack complex
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